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research-and-clinical-trials

Community programs increase aspirin use among individuals at high-risk for heart disease

Community-based programs combining a public health media campaign and health professional education have been shown to improve population-based aspirin use to reduce heart attack and stroke risk, according to new research from the Lillehei Heart Institute and School of Public Health at the University of Minnesota.

Results were published in the Center for Disease Control and Prevention’s journal Preventing Chronic Disease.

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news-and-notes

Two U of M researchers honored with prestigious NIH awards

The National Institutes of Health (NIH) recently recognized two University of Minnesota doctors for excellence in biomedical research. Demetris Yannopoulos, M.D., a Lillehei Heart Institute researcher and interventional cardiologist with University of Minnesota Physicians Heart at Fairview, received the Transformative Research award and Anna Tischler, Ph.D., a microbiologist within the University of Minnesota Medical School, was honored with the New Innovator award.

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patient-care

Positivity and physical activity remain key in the fight against cardiovascular disease

Two recent studies have armed cardiologists with even more evidence that a positive mindset and physical activity can reduce the risk and impact of cardiovascular disease.

First, in late September researchers from Tillburg University in the Netherlands announced results of a new study that found positivity might go a long way in helping people survive manage their heart disease.

Then, in a second study published earlier this month in the British Medical Journal, a research team comprised of experts from the London School of EconomicsHarvard Medical School and the Stanford University School of Medicine found that physical activity and exercise was often as effective as medical intervention in managing conditions like heart disease, heart failure and pre-diabetes.

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expert-perspectives

U of M expert perspective: Understanding the differences in heart attack symptoms in men and women

Thanks in part to decades of conditioning, a majority of the general public still believes that the ultimate telltale sign of a heart attack centers around one symptom: chest pain.

But now, new research from the Research Institute of the McGill University Health Centre in Canada has found that in young and middle-aged women, chest pain might not be the first signal a heart attack is occurring.

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research-and-clinical-trials

U of M researchers discover link between heart, blood, and skeletal muscle

New research out of the Lillehei Heart Institute at the University of Minnesota shows that by turning on just a single gene, Mesp1, different cell types including the heart, blood and muscle can be created from stem cells. The study was published in the journal Cell Stem Cell.

“Previous research indicated that this gene was the “master regulator” for development of the heart, and that its activity prevented the differentiation of other cell types,” said Michael Kyba, Ph.D., associate professor in the University of Minnesota Medical School Department of Pediatrics and a Lillehei endowed scholar. “Our work reveals that this gene acts differently, and that it plays a role in the development of blood and skeletal muscle as well.  The outcome depends on the chemical signals that cells expressing this factor sense in their environment.”

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research-and-clinical-trials

U of M researchers utilize genetically corrected stem cells to spark muscle regeneration

Researchers at the University of Minnesota’s Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

The research, which provides proof-of-principle for the feasibility of combining induced pluripotent stem cell technology and genetic correction to treat muscular dystrophy, could present a major step forward in autologous cell-based therapies for DMD and similar conditions and should pave the way for testing the approach in reprogrammed human pluripotent cells from muscular dystrophy patients.

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