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research-and-clinical-trials

Drug design for Parkinson’s disease starts here

Were drug design a road, it would surely be a Minnesota street fraught with potholes, ice and gravel.

Even the best ideas can fall by the wayside somewhere between the lab and your corner pharmacy in the process of drug discovery and development.

Recently, University of Minnesota Center for Drug Design member, organic chemist and assistant professor Liqiang Chen, Ph.D., published a paper in the Journal of Medicinal Chemistry outlining the discovery of a potent and selective protein-inhibitor. Blocking the protein, Sirtuin 2 (SIRT2), also has the potential to block a primary contributor to Parkinson’s disease from causing harm.

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in-the-news

Family dinners may decrease risk of obesity for children

Although sit down family dinners are most commonly used to strengthen a family’s bond, a new study from the University of Minnesota shows eating dinner together has more than just emotional benefits.

According to the study recently published in the Journal of Pediatrics, having just one sit down family dinner each week can decrease the risk of obesity for adolescents later in life.

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research-and-clinical-trials

University of Minnesota study: More effective alcohol policies ignored while less effective passed into law

What works to prevent alcohol-related deaths and binge drinking isn’t always what makes it into law. A new study finds that policymakers are significantly more likely to adopt ineffective alcohol policies than they are to adopt effective ones. Researchers at the University of Minnesota and Boston University tracked 29 different state alcohol control policies from 1999 through 2011 and found that that none of the policies rated to be the most effective for reducing excessive drinking were either adopted or strengthened during the study period. During that same period they noted an increase in adoption of policies that were comparatively less effective, or that targeted only youth drinking or impaired driving.

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in-the-news

In the News: A new idea for treating Alzheimer’s

Ling Li is taking Alzheimer’s disease research in a new direction.

Recently, Scientific American took a minute to feature her preliminary research into a novel approach to Alzheimer’s drug development.

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in-the-news

Mandated decrease in work hours may not be advantageous for neurosurgical residents

In an effort to decrease the amount of medical errors due to fatigue, in 2003 the Accreditation Council for Graduate Medical Education (ACGME) imposed a mandatory maximum 80-hour work-week restriction on medical residents.

Before this mandate, residents often worked more than 100 hours per week and some neurosurgery residents in particular worked in excess of 120 hours per week. A University of Minnesota study recently  published in the Journal of Neurosurgery now finds the mandate could be leaving neurosurgery residents underprepared.

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research-and-clinical-trials

Can this drug for Tylenol overdose make inroads with Type 1 diabetes?

A low-cost Tylenol overdose drug already available for cystic fibrosis use will soon enter clinical trials aimed at discovering whether it can aid in treating an additional condition: Type 1 diabetes.

The drug, a natural supplement, is thought to have potential use in the treatment of hypoglycemia, a condition in which too little blood sugar is present in the body.

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